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Inhibitory effects of Senkyu-chacho-san and Cnidii Rhizoma on catechol-O-methyltransferase
http://hdl.handle.net/10110/1655
http://hdl.handle.net/10110/1655177602f3-4e45-4772-9a38-9192bb46296c
名前 / ファイル | ライセンス | アクション |
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JtrMed04-kato.pdf (699.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-26 | |||||
タイトル | ||||||
タイトル | Inhibitory effects of Senkyu-chacho-san and Cnidii Rhizoma on catechol-O-methyltransferase | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parkinson's disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Catechol-O-methyltransferase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Senkyu-chacho-san | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-Hydroxy-ferulic acid | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kato, Atsushi
× Kato, Atsushi× Fukutake, Junko× Kizu, Haruhisa× Asano, Naoki× Adachi, Isao |
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著者別名 | ||||||
姓名 | 加藤, 敦 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the treatment for the symptoms of Parkinson's disease, the catechol-O-methyl transferase (COMT) inhibitors are expected to mitigate side effects, such as wearing-off, which are caused by long-term administration of L-DOPA. It has been reported that Senkyu-chacho-san causes dopamine increase in a rat striatum. However, the detailed mechanism has not been clarified about the mechanism. Search for components inhibiting COMT led to the discovery of active compounds contained in Cnidii Rhizoma (Senkyu). The hot water extract from the Cnidii Rhizoma was subjected to distribution or gel filtration chromatography to give ferulic acid (1), sinapic acid (2), 5-hydroxy-ferulic acid (3), and chlorogenic acid (4). Their structures were determined by spectroscopic analyses, particularly by extensive 1D and 2D NMR studies. Isolation of 3 is the first report from Cnidii Rhizoma. These compounds can be regarded as substratemimetics, and the number of the hydroxyl group in benzene nucleus seems to have a significant effect on inhibitory activity against COMT. Compound 3 inhibited COMT in a competitive manner and its Ki value was calculated 43 μM from Lineweaber-Burk plots. These results suggest that the phenylpropanoides, which are the components of Cnidii Rhizoma, might raise the dopamine level in the brain. パーキンソン病治療に汎用されている漢方薬のカテコール-O-メチル基転移酵素(COMT)に対する阻害効果を検討した。測定した6種の漢方方剤のうち,川芎茶調散と抑肝散に阻害活性が認められ,200μg/ml添加により,それぞれ89.8%,59.2%の阻害活性を示した。川芎茶調散の構成生薬に着目し同様の測定を行ったところ,川芎に強い阻害活性が認められ,20μg/ml添加により75.9%の強い阻害活性が見られた。また香附子と荊芥にも中程度の阻害が認められた。パーキンソン病に用いられる方剤の多くは,四逆散や芍薬甘草湯に代表されるように芍薬と甘草をベースとするものが多いが,芍薬と甘草には顕著なCOMT阻害活性は認められなかった。川芎から活性成分の単離を試みたところ,阻害物質としてferulic acid, sinapic acid, 5-hydroxyferulic acidおよびchlorogenic acidが単離できた。このうちメタ位に水酸基が配位している5-hydroxyferulic acid とchlorogenic acidには,比較的強いCOMT阻害活性が認められた。また,5-hydroxyferulic acidはLineweaver-Burk Plotを作成して検討した結果,拮抗型の阻害様式を示した(Ki=43.2μM)。以上の結果から,川芎茶調散はパーキンソン病治療にあたり脳内L-DOPAあるいはdopamineレベルを増加させる可能性が示唆された。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 21, 号 1, p. 34-38, 発行日 2004-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18801447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |