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Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants
http://hdl.handle.net/10110/1967
http://hdl.handle.net/10110/1967f5beb405-d67f-4053-8c3d-2c14224f797b
名前 / ファイル | ライセンス | アクション |
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19990504.pdf (640.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Helicobacter pylori | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | steroidal alkaloid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ri-ro(li-lu, 藜蘆) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | verapatulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antibacterial agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Veratrum patulum | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tezuka, Yasuhiro
× Tezuka, Yasuhiro× ZHAO, Weijie× Ishii, Eiji× Kadota, Shigetoshi |
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著者別名 | ||||||
姓名 | 門田, 重利 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Anti-Helicobacter pylori (HP) activities were examined, by disc method, on three total alkaloid fractions and fourteen steroidal alkaloids obtained from three Veratrum plants ( V. manckii, V. nigrum var. ussuriense and V. patulum) , which are used as a name of "Li-lu (藜蘆)" to treat aphasia arising from apoplexy, wind type dysentery, jaundice, headache, scabies, chronic malaria, etc. Among them, verapatulin (12) and veratramine (13) revealed anti-HP activities, and the disc-minimum inhibitory concentration (disk-MIC) value (10 μg/ml) of 12 against two standard HP strains, NCTC11637 and NCTC11916, was higher than that of a clinically used antibiotic, erythromycin (≦0.013 μg/ml) , but was comparable to those of penicillin G (3.1 μg/ml and 1.6 μg/ml, respectively). 漢薬"藜蘆"として用いられている3種のヴェラトラム属植物(V.maackii, V.nigrum var.ussuriense and V.patulum)から得た総アルカロイドフラクション3種及ぴステロイドアルカロイド14種について,抗ヘリコバクター・ピロリ活性をディスク法で測定した。調べたステロイドアルカロイドの中で,ヴェラパツリン(12)及ぴヴェラトラミン(13)が抗ヘリコバクター・ピロリ活性を示した。ヴェラパツリン(12)のヘリコバグター・ピロリ標準株2種(NCTC11637及ぴNCTC11916)に対するdisk MIC値は10μg/mlであり,臨床で用いられる抗生物質のエリスロマイシン(≦0.013μg/ml)よりは弱いが,ペニシリンG(各標準株に対して3.1μg/ml,1.6μg/ml)と同程度であった。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 16, 号 5/6, p. 196-200, 発行日 1999-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |