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Human intestinal bacteria responsible for the metabolism of saikosaponins
http://hdl.handle.net/10110/1965
http://hdl.handle.net/10110/196566976b80-6009-4be7-97ec-60d7b0fae10d
名前 / ファイル | ライセンス | アクション |
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20000101.pdf (1.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Human intestinal bacteria responsible for the metabolism of saikosaponins | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Saikosaponins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human intestinal bacteria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bifidobacterium sp. Saiko | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Eubacterium sp.A-44 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gnotobiote rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MESELHY, MeselhyR.
× MESELHY, MeselhyR. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metabolism of saikosaponins by human intestinal bacteria is discussed in view of the results obtained during the last years. Saikosaponins (SAPs) were converted to prosaikogenins and saikogenins in order by a human fecal suspension and by the bacterial strains, Eubacterium sp. A-44, Bifidobacterium sp. Saiko-1 and Saiko-2, isolated from human feces. From E. sp. A-44, two glycosidases responsible for the stepwise hydrolysis of SAPs were isolated and characterized as saikosaponin-hydrolyzing β-D-glucosidase and prosaikogenin-hydrolyzing β-D-fucosidase. After the oral administration of saikosaponin b_1 (Sb_1) to germ-free rats, no metabolites were detected in their plasma, cecal contents and cumulative feces. However, considerable amounts of prosaikogenin A and saikogenin A were detected when Sb_1 was orally given to conventional or the E. sp. A-44-infected gnotobiote rats. Fecal and cecal activities of hydrolyzing saikosaponins were found in the gnotobiote and conventional rats. These findings provided direct evidence that saikosaponins-hydrolyzing bacteria are necessary for the appearance of their biologically active metabolites in the systemic circulation. | |||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 17, 号 1, p. 1-11, 発行日 2000-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |