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Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression
http://hdl.handle.net/10110/1962
http://hdl.handle.net/10110/1962c41195de-3bae-49bb-a7df-a458bcc92eb7
名前 / ファイル | ライセンス | アクション |
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20000105.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antidepressive effects | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 5-HT2C receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gene expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | current responce | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in situ hybridization | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Xenopus oocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | repeated administration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tohda, Michihisa
× Tohda, Michihisa× Abdel-Fattah, Abdel-FattahMohamed× Nakamura, Satoshi× Watanabe, Hiroshi |
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著者別名 | ||||||
姓名 | 渡辺, 浩司 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hochu-ekki-to (HET, Bu-Zhong-Yi-Qi-Tang, Formu]a repletionis animelis et supletionis medii) is one of the Kampo medicine which has been used for improving disturbance and imbalance in the homeostatic condition of the body. Repeated treatment with HET (5.7 g/kg as estimated galenicals, p.o.) enhanced the serotonin 2C subtype receptor (5-HT2CR) mRNA expression in rat brain as effectively as 20 mg/kg imipramine p.o. HET at only 5 μg/ml as estimated galenicals evoked two types of inward current: one was of the metabotropic type and the other was of the ionotropic type. The metabotropic type current, which was expected to have strong intensity compared with that evoked by serotonin, was blocked by prior treatment with 10 μM mianserin, an antagonist of 5-HT2CR. These results suggest that HET contains strong 5-HT2CR agonistic factor (s) . 補中益気湯の"益気"作用機序を明らかにする目的で,熱水抽出エキスのセロトニン2Cサブタイプ受容体(5-HT2CR)応答への作用を検討した。補中益気湯5.7g/kg(生薬換算量)およぴイミプラミン20mg/kgを1日l回4日間ラットに経口投与したところ,脳内5-HT2CRmRNA量が有意に増大した。ラット脳mRNA移入アフリカツメガエル卵母細胞再構成系において,補中益気湯はわずか5μg/ml(生薬換算量)の添加で,代謝性とイオンチャネル性の二種の強い内向き電流応答を示した。そのうち代謝性の応答は5-HT2CR遮断薬である10μMミアンセリンの前処置で完全に消失した。以上の結果より,補中益気湯は5-HT2CRを賦活化する作用を有し,それを介して抗うつ薬様効果がもたらされるものと推定された。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 17, 号 1, p. 34-40, 発行日 2000-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |