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Chiyu extract stimulates antioxidant defense ability in senescence-accelerated mice
http://hdl.handle.net/10110/1959
http://hdl.handle.net/10110/195940a20e76-052c-4b7f-8684-6edc0f59f11c
名前 / ファイル | ライセンス | アクション |
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20000204.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Chiyu extract stimulates antioxidant defense ability in senescence-accelerated mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chiyu | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sanguisorba officinalis L. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | senescence-accelerated mice(SAM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glutathione redox cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | malondialdehyde | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yokozawa, Takako
× Yokozawa, Takako× Chen, CuiPing× Kitani, Kenichi |
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著者別名 | ||||||
姓名 | 横澤, 隆子 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of chiyu extract on antioxidant defense alteration in senescence-accelerated mice (SAM) was examined. Comparison with AKR/N Slc mice, a strain consistent with SAM but exhibiting normal aging, showed a lower glutathione (GSH) level and glutathione/glutathione disulfide (GSH/ GSSG) ratio in the kidney and liver of SAM, whereas malondialdehyde (MDA), a lipid peroxidation product, was increased significantly. Administration of chiyu extract increased the GSH level and GSH/ GSSG ratio, and markedly suppressed MDA production. On the other hand, detection of renal enzymes related to the glutathione redox cycle showed that catalase and glutathione peroxidase activities were largely decreased in SAM, whereas chiyu extract reversed this tendency. The reduced activities of hepatic catalase and glutathione reductase were increased significantly by the extract. These findings suggest that a decline of the antioxidant defense system occurs in SAM, and that chiyu extract may have a beneficial effect in ameliorating oxidative stress or damage. 老化促進マウス(SAM)の抗酸化防御機構に対し,地楡エキスがいかなる影響を及ぼしているかについて,SAMと同じ系統ではあるが,通常の老化過程を辿るAKR/N Slcマウスと比較検討した。その結果,SAMの腎,肝グルタチオンレベルとグルクチオン/グルタチオンジスルフィド比は低下し,脂質過酸化物のマロンジアルデヒドは逆に有意に上昇していたが,地楡エキスを投与したSAMでは,これらパラメーターがいずれも改善していた。一方,グルタチオン酸化還元サイクルに関係している酵素のうち,腎ではカタラーゼとグルクチオンペルオキシダーゼ活性がSAMで著しく低下し,地楡エキス投与によってこれら酵素の活性が回復していた。肝においても低下していたカタラーゼとグルタチオンレダクターゼ活性がエキス投与により著しく回復していた。これら所見は,SAMで認められる抗酸化防御系の低下が,地楡エキスによって是正されることを示唆するものである。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 17, 号 2, p. 73-79, 発行日 2000-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |