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Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury
http://hdl.handle.net/10110/1948
http://hdl.handle.net/10110/194812b01750-7fa0-4ca0-901e-a0a66930b51f
名前 / ファイル | ライセンス | アクション |
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20010101.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-24 | |||||
タイトル | ||||||
タイトル | Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sanguisorbae Radix | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroxynitrite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 3-nitrotyrosine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA fragmentation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | renal function | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
CHEN, CuiPing
× CHEN, CuiPing× Yokozawa, Takako× Sekiya, Michiko× Hattori, Masao× Tanaka, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 3-Nitrotyrosine, an oxidative product of protein that is produced via peroxynitrite (ONOO^-) nitration, was detected by HPLC analysis in plasma obtained from rats injected with lipopolysaccharide (LPS) and subjected to renal ischemia followed by reperfusion (LPS+ischemia-reperfusion), but not in rats subjected to sham-treatment. Rats pretreated with Sanguisorbae Radix extract orally for 30 days before LPS+ischemia-reperfusion, had lower 3-nitrotyrosine levels than rats without the pretreatment. Plasma levels of urea nitrogen and creatinine, indicators of renal dysfunction, were markedly lower in the animals pretreated with Sanguisorbae Radix extract than in those without the pretreatment. In addition, DNA fragmentation in renal tissues was significantly inhibited by administration of Sanguisorbae Radix prior to LPS+ischemia-reperfusion. These results suggest that Sanguisorbae Radix extract ameliorates oxidative damage caused by ONOO^-. パーオキシナイトライトは蛋白中のチロシンをニトロ化して3-ニトロチロシンを生成するが,この3-ニトロチロシンをHPLCで測定した結果,リポポリサッカライドと虚血-再灌流を施したラット血漿で検出され,偽処理した場合には検出されなかった。一方,リポポリサッカライドと虚血-再灌流を施す前に30日間地楡エキスを経口投与したラットでは,非投与群より低い3-ニトロチロシン値を示し,腎機能の指標の血漿尿素窒素,クレアチニンレベルも著しく低下していた。また腎組織中のDNA断片化も抑制され,地楡エキスがパーオキシナイトライトによる酸化的損傷を軽減することが推測された。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 18, 号 1, p. 1-7, 発行日 2001-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |