WEKO3
アイテム
{"_buckets": {"deposit": "1185f632-0265-48d2-8dd5-e4fd0b9c73b5"}, "_deposit": {"created_by": 3, "id": "5272", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5272"}, "status": "published"}, "_oai": {"id": "oai:toyama.repo.nii.ac.jp:00005272", "sets": ["648"]}, "author_link": ["159198", "159196", "159199", "159200", "159197"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "61", "bibliographicPageStart": "57", "bibliographicVolumeNumber": "20", "bibliographic_titles": [{"bibliographic_title": "和漢医薬学雑誌 = Journal of traditional medicines"}]}]}, "item_2_description_15": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aemotoxylon campechanumの血糖降下作用をSTZ誘発糖尿病ラットを用いて検討したところ,水エキスが空腹時血糖を有意かつ用量依存的に低下させた。そこで,水エキスをメタノール可溶性フラクション及び水溶性フラクションに分画したところ,メタノール可溶性フラクションがより強い作用を示し,100mg/kgの腹腔内投与で空腹時血糖値を37%低下させた。また,水エキス200mg/kg及びメタノール可溶部100mg/kgは空腹時血糖値を35.1%低下させた陽性コントロールとして用いたtolbutamide(100mg/kg)とbuformin(1mg/kg)の混合物よりも強いものであった。最後に,この活性フラクションの分離を行ない,グアイアン型セスキテルペン5種及びクマリン誘導体1種を単離・同定した。\n Hypoglycemic activity of Aemotoxylon campechanum was examined in STZ-induced diabetic rats. The water extract of A. campechanum lowered fasting blood glucose level of STZ-induced diabetic rats significantly and dosedependently. The water extract further divided into MeOH and H_2O-soluble fractions. The MeOH-soluble fraction showed the strongest hypoglycemic effect, which lowered fasting blood glucose level by 37% at a dose of 100 mg/kg (i. p.). The water extract and the MeOH-soluble fraction were found to be more effective in lowering the blood glucose level of diabetic rats than the mixtures of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as positive control, which lowered blood glucose level by 35.1%. The active fraction led to isolation of five guainane-type sesquiterpenes and a coumarin derivative.", "subitem_description_type": "Abstract"}]}, "item_2_description_40": {"attribute_name": "資源タイプ(DSpace)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_2_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "159200", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "門田, 重利"}]}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "和漢医薬学会"}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN10486121", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13406302", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "BANSKOTA, ArjunH."}], "nameIdentifiers": [{"nameIdentifier": "159196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Li, Jianping"}], "nameIdentifiers": [{"nameIdentifier": "159197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tezuka, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "159198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kadota, Shigetoshi"}], "nameIdentifiers": [{"nameIdentifier": "159199", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "20030203.pdf", "filesize": [{"value": "674.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 674000.0, "url": {"label": "20030203.pdf", "url": "https://toyama.repo.nii.ac.jp/record/5272/files/20030203.pdf"}, "version_id": "e5bfc88c-8948-4955-a454-02e9d2dfc4d9"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Aematoxylon campechanum", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hypoglycemic effect", "subitem_subject_scheme": "Other"}, {"subitem_subject": "streptozotocin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "guainane-type sesquiterpene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "coumarin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats"}]}, "item_type_id": "2", "owner": "3", "path": ["648"], "permalink_uri": "http://hdl.handle.net/10110/1907", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-01-23"}, "publish_date": "2008-01-23", "publish_status": "0", "recid": "5272", "relation": {}, "relation_version_is_last": true, "title": ["Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats"], "weko_shared_id": -1}
Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats
http://hdl.handle.net/10110/1907
http://hdl.handle.net/10110/1907fd376d3c-cb80-4339-89be-2ed7236d7bdd
名前 / ファイル | ライセンス | アクション |
---|---|---|
20030203.pdf (674.0 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-01-23 | |||||
タイトル | ||||||
タイトル | Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aematoxylon campechanum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypoglycemic effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | streptozotocin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | guainane-type sesquiterpene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | coumarin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
BANSKOTA, ArjunH.
× BANSKOTA, ArjunH.× Li, Jianping× Tezuka, Yasuhiro× Kadota, Shigetoshi |
|||||
著者別名 | ||||||
姓名 | 門田, 重利 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Aemotoxylon campechanumの血糖降下作用をSTZ誘発糖尿病ラットを用いて検討したところ,水エキスが空腹時血糖を有意かつ用量依存的に低下させた。そこで,水エキスをメタノール可溶性フラクション及び水溶性フラクションに分画したところ,メタノール可溶性フラクションがより強い作用を示し,100mg/kgの腹腔内投与で空腹時血糖値を37%低下させた。また,水エキス200mg/kg及びメタノール可溶部100mg/kgは空腹時血糖値を35.1%低下させた陽性コントロールとして用いたtolbutamide(100mg/kg)とbuformin(1mg/kg)の混合物よりも強いものであった。最後に,この活性フラクションの分離を行ない,グアイアン型セスキテルペン5種及びクマリン誘導体1種を単離・同定した。 Hypoglycemic activity of Aemotoxylon campechanum was examined in STZ-induced diabetic rats. The water extract of A. campechanum lowered fasting blood glucose level of STZ-induced diabetic rats significantly and dosedependently. The water extract further divided into MeOH and H_2O-soluble fractions. The MeOH-soluble fraction showed the strongest hypoglycemic effect, which lowered fasting blood glucose level by 37% at a dose of 100 mg/kg (i. p.). The water extract and the MeOH-soluble fraction were found to be more effective in lowering the blood glucose level of diabetic rats than the mixtures of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as positive control, which lowered blood glucose level by 35.1%. The active fraction led to isolation of five guainane-type sesquiterpenes and a coumarin derivative. |
|||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 20, 号 2, p. 57-61, 発行日 2003-04 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |