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Chemical and pharmaceutical evaluation of Daitou-Gancao in comparison with usual Glycyrrhizae Radices
http://hdl.handle.net/10110/1904
http://hdl.handle.net/10110/19048a734eb6-4a63-4e9b-9d92-b951a2515460
名前 / ファイル | ライセンス | アクション |
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wakan03-102.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-22 | |||||
タイトル | ||||||
タイトル | Chemical and pharmaceutical evaluation of Daitou-Gancao in comparison with usual Glycyrrhizae Radices | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glycyrrhiza uralensis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glycyrrhizin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HPLC fingerprint | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | principal component analysis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | allergic inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamamoto, Yutaka
× Yamamoto, Yutaka× Majima, Takami× He, Ju-Xiu× Saiki, Ikuo× Tani, Tadato |
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著者別名 | ||||||
姓名 | 山本, 豊 | |||||
著者別名 | ||||||
姓名 | 済木, 育夫 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 1997年以降に中国から輸入されている帯頭甘草(Daitou-Gancao : 中国市場の名称)の化学的薬理薬剤学的な特性を評価した。まず,帯頭甘草の基原は,日本薬局方(JPXIV)に適合するGlycyrrhiza uralensis FlSCH.であることを産地(陝西省と甘粛省)調査から確認した。次に帯頭甘草のerlycyrrhizin(GL)を含むHPLC fingerprintは,G.uralensisの根と薬用の東北甘草(Dongbei-Gancao)や西北甘草(Xibei-Gancao)に類似し,JP XIVに適合しない新疆甘草(Xinjiang-Gancao)と異なることを明らかにした。米国FDAは植物由来製品をfingerprintで規格評価することを推奨している。この方法の普及を目指して,fingerprintをbar codeに簡略表示することを試みた。なおHPLC profileの定性的な判定結果をprincipal component analysis(PCA)やhierarchical cluster analysis(HCA)によって客観的に裏づけした。また帯頭甘草がJP XIVの5種類の規格試験に適合することも明らかにした。さらに帯頭甘草の抗アレルギー作用(IgE介在性のマウス耳介腫脹反応)とglycyrrhetic acid(GLの代謝物)の動態は,薬用の東北甘草と同等であることを薬理薬剤学的に検証した。今回の研究によって,帯頭甘草(陝西省と甘粛省の特定地域に野生するG.uralensisの根から調製される甘草)がJP XIV に適合し薬用資源に成り得ることが明らかになった。本論文は中国における産地や流通経路の変動に伴って新たに輸入されてきた帯頭甘草の規格を,含有成分の比較だけでなく薬理薬剤学的にも検討した点に特徴がある。 The chemical and pharmaceutical characteristics of Daitou-Gancao (Taito-Kanzo in Japanese), which is a newly imported Chinese Glycyrrhizae Radix from about 1997 in order to make up for the deficit of Dongbei-Gancao (Tohoku-Kanzo in Japanese) was studied. Its botanical origin was identified as Glycyrrhiza uralensis FISCH., by on-the-spot investigations in the Gansu and Shanxi provinces of China. The HPLC fingerprint of Daitou-Gancao was similar to that of two concurrent medicinal Dongbei- and Xibei-Gancao (Seihoku-Kanzo), but different from that of Xinjiang-Gancao (Shinkyo-Kanzo), which does not conform to the Japanese Pharmacopoeia XIV standard. Daitou-Gancao and the medicinal Dongbei- and Xibei-Gancao were also clearly distinguishable from non-medicinal Xinjiang-Gancao by principal component analysis and hierarchical cluster analysis using 7 HPLC-peak-area data. Furthermore, Daitou-Gancao had an anti-allergic effect and pharmacokinetic profile of glycyrrhetic acid, an active metabolite of glycyrrhizin, similarly to Dongbei-Gancao. The present chemical and pharmaceutical study suggests that Daitou-Gancao could be used concurrently with Dongbei- and Xibei-Gancao, which conform to the JP XIV. |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 20, 号 3, p. 102-110, 発行日 2003-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |