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Screening of medicinal plant extracts for estrogenic activity in combination with a glycosidase treatment
http://hdl.handle.net/10110/1393
http://hdl.handle.net/10110/1393a0ae226b-8b98-43fa-9508-4460b54acda2
名前 / ファイル | ライセンス | アクション |
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wakan04-hattori.pdf (555.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-18 | |||||
タイトル | ||||||
タイトル | Screening of medicinal plant extracts for estrogenic activity in combination with a glycosidase treatment | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phytoestrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MCF-7 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | yeast two-hybrid assay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | naringinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | エストロゲン活性 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
AGB, Eun-Mi
× AGB, Eun-Mi× Akao, Teruaki× Nakamura, Norio× Komatsu, Katsuko× Nishimura, Tsutomu× Hattori, Masao |
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著者別名 | ||||||
姓名 | 服部, 征雄 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | For the purpose of evaluating phytoestrogenic activity of medicinal plant extracts, a naringinase-pretreatment method was developed, monitoring with proliferation of MCF-7 human breast cancer cells and induction of β-galactosidase in a yeast two-hybrid assay system. 0f various medicinal plant extracts examined, the extracts of Alpinia katsumadai (seeds), Glycyrrhiza uralensis (roots) and Moghania philippinensis (roots) showed higher estrogenic activity by per-treatment with naringinase than the original extract themselves. The contents of liquiritigenin and isoliquiritigenin having potent estrogenic activity, appreciably increased after the naringinase treatment of the extract of G. uralensis. These findings suggested that orally administered crude drugs would increase their estrogenic activity, due to the hydrolysis of some glycosylated constituents by intestinal flora. 薬用植物エキスの植物エストロゲン活性を評価する目的で,naringinaseで前処理し,MCF-7ヒト乳癌細胞の増植反びyeast two-hybrid assay法によるβ-galactosidase活性の誘導を指標とする方法を開発した。検討したエキスの中でALpinia katsumadai, Glycyrrhiza uralensis, Moghania philippinensisはnaringinase処理することにより,元のエキスよりエストロゲン活性が強くなった。G. uralensisのエキスをnaringinase処理すると,エストロゲン活性のあるliquiritigeninとisoliquiritigeninの含有量は顕著に増加した。この結果は,生薬を経口投与すると場内細菌による配糖体の加水分解が起り,エストロゲン活性が増大することを示唆している。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 21, 号 2, p. 81-86, 発行日 2004-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18801447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |