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Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain
http://hdl.handle.net/10110/226
http://hdl.handle.net/10110/226e2e43fa9-bee8-4e8e-9533-4891cda9e3d0
名前 / ファイル | ライセンス | アクション |
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MOR-PHN.pdf (212.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-07-26 | |||||
タイトル | ||||||
タイトル | Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Postherpetic neuralgia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Herpes zoster | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Opioid receptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Morphine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nalfurafine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Analgesia | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takasaki, Ichiro
× Takasaki, Ichiro× Nojima, Hiroshi× Shiraki, Kimiyasu× Kuraishi, Yasushi |
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著者別名 | ||||||
姓名 | 高崎, 一朗 | |||||
著者別名 | ||||||
姓名 | 野島, 浩史 | |||||
著者別名 | ||||||
姓名 | 白木, 公康 | |||||
著者別名 | ||||||
姓名 | 倉石, 泰 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation. Morphine inhibited herpetic pain more effectively than postherpetic pain. Intrathecal injection reduced the analgesic effects of morphine on postherpetic pain, but intracerebroventricular injection did not. The κ-opioid receptor agonist nalfurafine suppressed herpetic and postherpetic pain to similar degrees. μ-Opioid receptor-like immunoreactivities in the lumbar dorsal horn were markedly decreased at the postherpetic, but not herpetic, stage of pain. In the dorsal root ganglia, the expression of μ-opioid receptor mRNA was significantly decreased in mice with postherpetic pain, whereas the κ-opioid receptor mRNA level was not altered. These results suggest that specific down-regulation of the μ-opioid receptor in the primary sensory neurons is responsible for the reduced analgesic action of morphine on postherpetic pain. The κ-opioid receptor may be a useful target for the analgesic treatment of postherpetic neuralgia. | |||||
書誌情報 |
European Journal of Pharmacology 巻 550, 号 1-3, p. 62-67, 発行日 2006-11-21 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0014-2999 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00639687 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17026987 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejphar.2006.08.041 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |