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Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones
http://hdl.handle.net/10110/11150
http://hdl.handle.net/10110/1115073f8791c-09fc-4359-b2da-4d7b59d4cf15
名前 / ファイル | ライセンス | アクション |
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ichijoBR2013.pdf (466.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-05 | |||||
タイトル | ||||||
タイトル | Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proteoglycan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chondroitin sulfate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | retina | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | axon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth cone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | circuit formation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimbo, Miki
× Shimbo, Miki× Ando, Satoru× Sugiura, Nobuo× Kimata, Koji× Ichijo, Hiroyuki |
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著者別名 | ||||||
姓名 | 一條, 裕之 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chondroitin sulfate (CS), the carbohydrate chain of chondroitin sulfate proteoglycans, is involved in neuronal circuit formation during development. CS shows great structural diversity with combination of disaccharide units of different structure (A-, C-, D-, or Eunit). However, whether its structural diversity contributes to pathway formation remains unclear. We chemically coupled the reducing end of various types of CS to the amino group of phosphatidylethanolamine (lipid-derivatized CS, CS-PE) and established an in vitro time-lapse assay to observe the behaviors of growth cones of retinal ganglion cells from embryonic day 6 chick retina on exposure to beads coated with lipid-derivatized CS (CS-PE beads). Among CS-PEs with different content of the structural units, the beads coated with E-unit–containing CS-PE [E-unit: GlcAβ1-3GalNAc(4,6-O-disulfate)] (CSE-PE beads) significantly caused the growth cones to retract and to turn away from the beads, but the beads coated with CSA-, CSC- or CSDPE beads did not. Importantly, not all the growth cones retracted equally from the CSE-PE beads, but they showed continuum of the repulsive behaviors; some behaved moderately and others remarkably. The growth cones distinguished different samples of CS: CSE and the others. Moreover, the continuum of the repulsive behaviors suggests that CS might be involved with the fine regulation of growth cones' behavior through its characteristic structure. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Brain Research 1491 (2013) 34-43 | |||||
書誌情報 |
Brain Research 号 1491, p. 34-43, 発行日 2013-01-23 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-8993 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA0057324X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.brainres.2012.11.011 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |