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Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous System during Development
http://hdl.handle.net/10110/11149
http://hdl.handle.net/10110/11149e7427818-b009-4b23-b0bc-9b2bda458dbf
名前 / ファイル | ライセンス | アクション |
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polymers-05-00254-2.pdf (372.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-05 | |||||
タイトル | ||||||
タイトル | Application of Chondroitin Sulfate Derivatives for Understanding Axonal Guidance in the Nervous System during Development | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proteoglycan | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chondroitin sulfate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | axon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | growth cone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | circuit formation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ichijo, Hiroyuki
× Ichijo, Hiroyuki× Sugiura, Nobuo× Kimata, Koji |
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著者別名 | ||||||
姓名 | 一條, 裕之 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neuronal axons and their growth cones recognize molecular guidance cues within the local environment, forming axonal pathways to produce precise neuronal networks during nervous system development. Chondroitin sulfates (CS), carbohydrate chains on chondroitin sulfate proteoglycans, exhibit great structural diversity and exert various influences on axons and growth cones as guidance cues or their modulators; however, the relationship between their structural diversity and function in axonal guidance is not well known. To uncover the roles of CS in axonal guidance, artificially modified hybrid molecules: CS derivatives of biotinylated CS and lipid-derivatized CS, were used. The experiments with biotinylated CS suggest that the growing axons act on their environment, modifying CS, and rendering it more favorable for their growth. The experiments with lipid-derivatized CS demonstrated that growth cones distinguish types of CS with different unit contents and are likely to discriminate the structural diversity of CS. The application of CS derivatives is useful in uncovering axon–environment interaction and structure–function relationship of CS directly. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Polymers 2013, 5(1), 254-268 | |||||
書誌情報 |
Polymers 号 5, p. 254-268, 発行日 2013-02-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2073-4360 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/polym5010254 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | MDPI, Basel, Switzerland | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |