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Biological Effects of Low Intensity Ultrasound : The Mechanism Involved, and its Implications on Therapy and on Biosafety of Ultrasound
http://hdl.handle.net/10110/2505
http://hdl.handle.net/10110/250555e35f8d-d5c9-418d-9c57-c083159af291
名前 / ファイル | ライセンス | アクション |
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JRadiatRes04-479.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-07 | |||||
タイトル | ||||||
タイトル | Biological Effects of Low Intensity Ultrasound : The Mechanism Involved, and its Implications on Therapy and on Biosafety of Ultrasound | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Low intensity ultrasound | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bioeffects | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Biosafety | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
FERIL, LoretoB.
× FERIL, LoretoB.× Kondo, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The biological effects of low intensity ultrasound (US) in vitro; the mechanisms involved; and the factors that can enhance or inhibit these effects are reviewed. The lowest possible US intensities required to induce cell killing or to produce free radicals were determined. Following sonication in the region of these intensities, the effects of US in combination with either hyperthermia, hypotonia, echo-contrast agents (ECA), CO_2, incubation time, high cell density or various agents were examined. The results showed that hyperthermia, hypotonia and microbubbles are good enhancers of the bioeffects, while CO_2, incubation time and high cell density are good inhibitors. Cellular membrane damage is pivotal in the events leading to cell death, with the cellular damage-and-repair mechanism as an important determinant of the fate of the damaged cells. The optimal level of apoptosis (with minimal lysis) and optimal gene transfection efficiency were attained using a pulsed low intensity US. In summary, the findings suggest that low intensity US is potentially useful in therapy, while on the other hand, they also call for further investigation of such clinical scenarios as high-grade fever, edema or use of ECA which may lead to the lowering of the threshold for bioeffects with diagnostic US. | |||||
書誌情報 |
Journal of radiation research 巻 45, 号 4, p. 479-489, 発行日 2004-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 4493060 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00705792 | |||||
権利 | ||||||
権利情報 | rights: 本文データは、日本放射線影響学会の許諾に基づき、CiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 日本放射線影響学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |