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Inhibitory effects of Cinnamomi Cortex and cinnamaldehyde on oxygen-derived free radical-induced vasocontraction in isolated aorta of spontaneously hypertensive rats
http://hdl.handle.net/10110/1919
http://hdl.handle.net/10110/1919ad2470ef-b615-4998-ae89-c4607104890b
名前 / ファイル | ライセンス | アクション |
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20020203.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-23 | |||||
タイトル | ||||||
タイトル | Inhibitory effects of Cinnamomi Cortex and cinnamaldehyde on oxygen-derived free radical-induced vasocontraction in isolated aorta of spontaneously hypertensive rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cinnamomi Cortex | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cinnamaldehyde | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vasocontraction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spontaneously hypertensive rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phospholipase A_2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | thromboxane A_2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelial dysfunction | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kasahara, Yuji
× Kasahara, Yuji× Goto, Hirozo× Shimada, Yutaka× Sekiya, Nobuyasu× YANG, Qiao× Terasawa, Katsutoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 自然発症高血圧ラット(SHR)摘出胸部大動脈におけるキサンチン-キサンチンオキシダーゼ(XOD)誘発血管収縮反応に対する桂皮エキスおよびケイヒアルデヒド(CA)の収縮抑制作用についてオルガンバス法を用いて検討した。キサンチン-XOD誘発血管収縮反応は,SHR対照群と比較して,桂皮エキス(10^<-4>g/ml)前処置群,CA(10^<-4>M)前処置群で,有意に抑制されていた。キサンチン-XOD収縮反応時のトロンボキサンB_2(TXB_2)産生量は,SHR対照群と比較して,桂皮エキス(10^<-4>g/ml)群,CA(10^<-4>M)群で,有意に抑制されていた。CAのTX産生抑制の機序を検討するため,フォスフォリパーゼA_2(PLA_2)誘発血管収縮反応に対する収縮抑制作用について検討したところ,PLA_2誘発血管収縮反応はSHR対照群と比較して,CA(10^<-4>M)群で,有意に抑制されていた。PLA_2収縮反応時のTXB_2産生量は,SHR対照群と比較してCA(10^<-4>M)群で,有意に抑制されていた。以上のことから,桂皮は,血管収縮因子であるTXA_2抑制作用を持つ生薬である可能性が示唆された。 We examined the inhibiting effect of Cinnamomi Cortex extract (CCE) and cianamaldehyde (CA) against vasocontraction induced by oxygen-derived free radicals produced by the xanthine-xanthine oxidase (XOD) system in the thoracic aortic ring of the spontaneously hypertensive rat (SHR), using the organ bath method in vitro. The vasocontraction induced by xanthine-XOD in the CCE (10^<-4>g/ml) and CA (10^<-4>M) treatment groups were significantly lower than that in the control group. Further, the amounts of thromboxane B_2 (TXB_2) produced in the vasocontractive response in the CCE (10^<-4>g/ml) and CA (10^<-4>M) treatment groups were significantly lower than that in the control group. For the purpose of examining the mechanism of the inhibiting effect of CA against thromboxane production, the inhibiting effect of CA against the vasocontraction induced by phospholipase A_2 (PLA_2) was examined. The vasocontraction induced by PLA_2 in the CA (10^<-4>M) treatment group was significantly lower than that in the control group. Moreover, the amount of TXB_2 produced by the vasocontractive response in the CA (10^<-4>M) treatment group was significantly lower than that in the control group. From the above findings, it is suggested that Cinnamomi Cortex is an agent which exerts an inhibitory effect on the vasocontractive factor (TXA_2) in vitro. |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 19, 号 2, p. 51-57, 発行日 2002-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-6302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |