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The Novel HMG-CoA Reductase Inhibitor, Pitavastatin, Induces a Protective Action in Vascular Endothelial Cells through the Production of Nitric Oxide (NO)
http://hdl.handle.net/10110/1754
http://hdl.handle.net/10110/17547e6bb47c-b2e1-439e-a752-6b63fd2b73de
名前 / ファイル | ライセンス | アクション |
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yakugakuzasshi04-121.pdf (824.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-10 | |||||
タイトル | ||||||
タイトル | The Novel HMG-CoA Reductase Inhibitor, Pitavastatin, Induces a Protective Action in Vascular Endothelial Cells through the Production of Nitric Oxide (NO) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitric oxide (NO) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vascular endothelial cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pitavastatin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tokoro, Takashi
× Tokoro, Takashi× Wang, Juyong× Kitajima, Isao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study sought to induce the effect of nitric oxide (NO) production in vascular endothelial cells by Pitavastatin, which is a novel HMG-CoA reductase inhibitor (statin). The growth capacity of vascular endothelial cells significantly (p<0.01) declined when stimulated with TNF-α (10 ng/ml). The growth capacity of the TNF-α treated cells recovered, when the TNF-α stimulation was performed after Pitavastatin (100 nM) pretreatment. The recovery of the growth capacity of the cells was suppressed by the presence of the NO synthase inhibitor, L-NAME. Pitavastatin increased NO production by the vascular endothelial cells in a dose and time dependent manner. The NO production was suppressed by the presence of mevalonic acid and geranylgeranyl pyrophosphate. In addition, the expression of endothelial nitric oxide synthase was strongly induced by Pitavastatin, and was suppressed by mevalonic acid and geranylgeranyl pyrophosphate by Western blot analysis. Our results show that Pitavastatin induces NO production by vascular endothelial cells, and protects vascular endothelial cells from injury due to the inflammatory reaction induced by TNF-α. | |||||
書誌情報 |
藥學雜誌 : Journal of the Pharmaceutical Society of Japan (薬学雑誌) 巻 124, 号 3, p. 121-126, 発行日 2004-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00316903 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 社団法人日本薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |