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In vitro effects of zinc on the cytokine production from peripheral blood mononuclear cells in patients with zinc allergy.
http://hdl.handle.net/10110/00018294
http://hdl.handle.net/10110/00018294f56dbe60-c3db-4dda-ad6a-d68624cce22f
名前 / ファイル | ライセンス | アクション |
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Springerplus_4_404_Yoshihisa (833.2 kB)
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Creative Commons : 表示 - 4.0 国際
https://creativecommons.org/licenses/by/4.0/deed.ja |
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-12 | |||||
タイトル | ||||||
タイトル | In vitro effects of zinc on the cytokine production from peripheral blood mononuclear cells in patients with zinc allergy. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vitro effects of zinc on the cytokine production from peripheral blood mononuclear cells in patients with zinc allergy. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cytokines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PBMCs | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Zinc | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoshihisa, Yoko
× Yoshihisa, Yoko× Rehman, Mati Ur× Yamakoshi-Shibutani, Takako× Shimizu, Tadamichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Metals, such as nickel, cobalt, chromium and zinc, are ubiquitous in the environment. Systemic reactions, including hand dermatitis and generalized eczematous reactions, can be caused by the dietary ingestion of metals. In this study, we aimed to determine whether the cytokine production from peripheral blood mononuclear cells (PBMCs) obtained from zinc allergy patients can be used as a sensitive marker to investigate zinc-allergic contact dermatitis. The diagnosis of sensitivity to metal was made based on the results of a metal patch test. The PBMCs were stimulated with various concentrations (5-100 μM) of zinc sulfate (ZnSO4) for 24 h. The culture supernatants were collected and analyzed using ELISA for measurement of the cytokine production. The levels of IFN-γ, TNF-α, IL-1β, IL-5, IL-13 and MIF were significantly higher in the zinc-allergic patients (n = 5) than in the healthy controls (n = 5) at 100 μM of ZnSO4 stimulation. Although, patch testing is considered as standard test to diagnose metal allergy but false-positive and -negative reactions may limit its use in conditions of existing dermatitis. Therefore, this study suggest that in support of patch testing the determination of cytokine production using PBMCs cultures would be helpful for making an early diagnosis of such conditions. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Springerplus. 2015 Aug 8;4:404 | |||||
書誌情報 |
en : SpringerPlus 巻 4, p. 404, 発行日 2015-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2193-1801 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 26261762 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1186/s40064-015-1202-5 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | SpringerPlus | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |