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Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents
http://hdl.handle.net/10110/00018234
http://hdl.handle.net/10110/000182342ecea3ca-e70d-46ef-bce3-365900782921
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_31_11_2126to2130_Toyooka (200.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-01 | |||||
タイトル | ||||||
タイトル | Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | L-type amino acid transporter 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amino acid-mustard | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alkylating agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inner blood-retinal barrier | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | L-type amino acid transporter 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | amino acid-mustard | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | alkylating agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inner blood-retinal barrier | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hosoya, Ken-ichi
× Hosoya, Ken-ichi× Kyoko, Hirokazu× Toyooka, Naoki× Kato, Atsushi× Orihashi, Masahiro× Tomi, Masatoshi× Tachikawa, Masanori |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Evaluation of Amino Acid-Mustard Transport as L-Type Amino Acid Transporter 1 (LAT1)-Mediated Alkylating Agents | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The L-type amino acid transporter 1 (LAT1, SLC7A5) is an Na+-independent neutral amino acid transporter the expression of which is located in retinal endothelial cells. Due to its broad substrate selectivity, LAT1 has been proposed to mediate the transport of amino acid-related drugs across the blood-tissue barriers. Here, we have investigated the transport screening of amino acid-mustards using a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB2) which expresses LAT1. We synthesized 5 amino acid-mustards: tyrosine-mustard, phenylglycine-mustard, alanine-mustard, ornithine-mustard, and lysine-mustard. LAT1-mediated [3H]L-phenylalanine (Phe) uptake by TR-iBRB2 cells was inhibited in a competitive manner by tyrosine-mustard and phenylglycine-mustard as well as melphalan (phenylalanine-mustard). Phenylglycine-mustard was able to induce the efflux of [3H]Phe preloaded into the TR-iBRB2 cells expressing LAT1 through the obligatory exchange mechanism, although tyrosine-mustard, alanine-mustard, ornithine-mustard, lysine-mustard, and melphalan did not induce any significant efflux. These findings suggest that phenylglycine-mustard is a better substrate for LAT1 than melphalan and other amino acid-mustards. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological and Pharmaceutical Bulletin 31(11), 2126-2130.(2008) | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin en : Biological and Pharmaceutical Bulletin 巻 31, 号 11, p. 2126-2130, 発行日 2008-11-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.31.2126 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110006968099 | |||||
出版者 | ||||||
出版者 | THE PHARMACEUTICAL SOCIETY OF JAPAN | |||||
出版者 | ||||||
出版者 | 公益社団法人日本薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |