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新規汎用性キラル素子の創製とその生物活性天然物合成への応用
http://hdl.handle.net/10110/00018233
http://hdl.handle.net/10110/000182336b5b2c7e-f2a8-4f88-8618-75ded03b256b
名前 / ファイル | ライセンス | アクション |
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YakugakuZasshi_121_7_467to479_Toyooka (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-01 | |||||
タイトル | ||||||
タイトル | 新規汎用性キラル素子の創製とその生物活性天然物合成への応用 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Synthesis and Its Application to the Synthesis of Biologically Active Natural Products of New and Versatile Chiral Building Blocks | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chiral building blocks | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dendrobates alkaloids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clavepictines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pictamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lepadin B, A(1,3) strain | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chiral building blocks | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dendrobates alkaloids | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clavepictines | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pictamine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lepadin B, A(1,3) strain | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
豊岡, 尚樹
× 豊岡, 尚樹 |
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著者別名 | ||||||
姓名 | Toyooka, Naoki | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | Synthesis and Its Application to the Synthesis of Biologically Active Natural Products of New and Versatile Chiral Building Blocks | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This article describes a design and synthesis of new and versatile chiral building blocks and its application to the biologically active natural product synthesis. The chiral building blocks were prepared using a biocatalysis in an enantiomerically pure state. As an application of the above chiral building blocks to the synthesis of biologically active natural product, we demonstrated the diastereodivergent synthesis of the 3-piperidinol alkaloids cassine, spectaline, prosafrinine, iso-6-cassine, prosophylline, prosopinine, and also established the flexible route to the 5,8-disubstituted indolizidine or 1,4-disubstituted quinolizidine type of Dendrobates alkaloids. As another application to the synthesis of biologically active alkaloids, we accomplished the first enantioselective total synthesis of marine alkaloids clavepictines A, B, and pictamine using a highly stereoselective Michael type quinolizidine ring closure reaction as the crucial step, and the first total synthesis of a marine alkaloid lepadin B was also achieved using aldol cyclization controlled by a A<SUP>(1,3)</SUP> strain. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 本総説は,平成12年度日本薬学会北陸支部学術奨励賞の受賞を記念して記述したものである. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 藥學雜誌 = Journal of the Pharmaceutical Society of Japan 12(7), 467-479.(2001) | |||||
書誌情報 |
藥學雜誌 = Journal of the Pharmaceutical Society of Japan en : YAKUGAKU ZASSHI 巻 121, 号 7, p. 467-479, 発行日 2001-07-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00316903 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00284903 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/yakushi.121.467 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110003648535 | |||||
出版者 | ||||||
出版者 | 公益社団法人日本薬学会 | |||||
出版者 | ||||||
出版者 | THE PHARMACEUTICAL SOCIETY OF JAPAN | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |