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NK cells control tumor-promoting function of neutrophils in mice
http://hdl.handle.net/10110/00018216
http://hdl.handle.net/10110/00018216d1ea7e15-05e9-46a7-99c3-60d73854618c
名前 / ファイル | ライセンス | アクション |
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CIR_Hayakawa (4.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2019-01-23 | |||||
タイトル | ||||||
タイトル | NK cells control tumor-promoting function of neutrophils in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ogura, Keisuke
× Ogura, Keisuke× Sato-Matsushita, Marimo× Yamamoto, Seiji× Hori, Takashi× Sasahara, Masakiyo× Iwakura, Yoichiro× Saiki, Ikuo× Tahara, Hideaki× Hayakawa, Yoshihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although NK cells are recognized as direct antitumor effectors, the ability of NK cells to control cancer-associated inflammation, which facilitates tumor progression, remains unknown. In this study, we demonstrate that NK cells control tumor-promoting inflammation through functional modification of neutrophils. NK cells control the tumor-promoting function of neutrophils through an IFNgamma-dependent mechanism. Tumor progression in an NK cell-depleted host is diminished when the IL17A-neutrophil axis is absent. In NK cell-depleted mice, neutrophils acquire a tumor-promoting phenotype, characterized by up-regulation of VEGF-A expression, which promotes tumor growth and angiogenesis. A VEGFR inhibitor which preferentially suppressed tumor growth in NK cell-depleted mice was dependent on neutrophils. Furthermore, the systemic neutropenia caused by an anti-metabolite treatment showed an anti-cancer effect only in mice lacking NK cells. Thus, NK cells likely control the tumor-promoting and angiogenic function of neutrophils. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Immunology Research , DOI: 10.1158/2326-6066.CIR-17-0204 | |||||
書誌情報 |
Cancer Immunology Research 巻 6, 号 3, 発行日 2018-03 |
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DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1158/2326-6066.CIR-17-0204 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | American Association for Cancer Research Pubblications | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
関係URI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1158/2326-6066 | |||||
関連名称 | 出版社版 |