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The N-methyl-D-aspartate (NMDA)-type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice.
http://hdl.handle.net/10110/00018183
http://hdl.handle.net/10110/0001818389769799-fdd4-4b29-a473-8dcf04bfb3a2
名前 / ファイル | ライセンス | アクション |
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NeuroSciLet_364_1_43to47_Kawahara (828.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-22 | |||||
タイトル | ||||||
タイトル | The N-methyl-D-aspartate (NMDA)-type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The N-methyl-D-aspartate (NMDA)-type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Analysis of Variance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Behavior, Animal | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blinking | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Conditioning (Psychology) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Female | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Learning Disorders | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Inbred C57BL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Mutant Strains | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Motor Activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Psychomotor Performance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Reaction Time | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Receptors, N-Methyl-D-Aspartate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takehara, Kaori
× Takehara, Kaori× Kawahara, Shigenori× Munemoto, yumi× Kuriyama, Hiromichi× Mori, Hisashi× Mishina, Masayoshi× Kirino, Yutaka |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | The N-methyl-D-aspartate (NMDA)-type glutamate receptor GluRepsilon2 is important for delay and trace eyeblink conditioning in mice. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It has been proposed that the N-methyl-d-aspartate (NMDA)-type glutamate receptor (GluR) plays an important role in synaptic plasticity, learning, and memory. The four GluRepsilon (NR2) subunits, which constitute NMDA receptors with a GluRzeta (NR1) subunit, differ both in their expression patterns in the brain and in their functional properties. In order to specify the distinct participation of each of these subunits, we focused on the GluRepsilon2 subunits, which are expressed mainly in the forebrain. We investigated delay and trace eyeblink conditioning in GluRepsilon2 heterozygous mutant mice whose content of GluRepsilon2 protein was decreased to about half of that in wild-type mice. GluRepsilon2 mutant mice exhibited severe impairment of the attained level of conditioned response (CR) in the delay paradigm, for which the cerebellum is essential and modulation by the forebrain has been suggested. Moreover, GluRepsilon2 mutant mice showed no trend toward CR acquisition in the trace paradigm with a trace interval of 500 ms, in which the forebrain is critically involved in successful learning. On the other hand, the reduction of GluRepsilon2 proteins did not disturb any basic sensory and motor functions which might have explained the observed impairment. These results are different from those obtained with GluRepsilon1 null mutant mice, which attain a normal level of the CR but at a slower rate in the delay paradigm, and showed a severe impairment in the trace paradigm. Therefore, the NMDA receptor GluRepsilon2 plays a more critical role than the GluRepsilon1 subunit in classical eyeblink conditioning. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Neuroscience letters 364(1), 43-47.(2004) | |||||
書誌情報 |
Neuroscience letters en : Neuroscience letters 巻 364, 号 1, p. 43-47, 発行日 2004-06-24 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0304-3940 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15193753 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.neulet.2004.04.024 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |