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The PLC and PKC isoforms that are involved in LTD remain unclear, however. One previous study found no change in LTD in PKCgamma-deficient mice, thus, in the present study, we examined cerebellar LTD in PLCbeta4-deficient mice. Immunohistochemical and Western blot analyses of cerebellum from wild-type mice revealed that PLCbeta1 was expressed weakly and uniformly, PLCbeta2 was not detected, PLCbeta3 was expressed predominantly in caudal cerebellum (lobes 7-10), and PLCbeta4 was expressed uniformly throughout. In PLCbeta4-deficient mice, expression of total PLCbeta, the mGluR1-mediated Ca(2+) response, and LTD induction were greatly reduced in rostral cerebellum (lobes 1-6). Furthermore, we used immunohistochemistry to localize PKCalpha, -betaI, -betaII, and -gamma in mouse cerebellar Purkinje cells during LTD induction. Both PKCalpha and PKCbetaI were found to be translocated to the plasmamembrane under these conditions. 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Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells.
http://hdl.handle.net/10110/00018179
http://hdl.handle.net/10110/0001817938bd4946-c4f7-43c0-8b51-275c655cd52f
名前 / ファイル | ライセンス | アクション |
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JBiolChem_276_48_45236to42_Kawahara (704.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-22 | |||||
タイトル | ||||||
タイトル | Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blotting, Western | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebellum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enzyme Activation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isoenzymes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Transgenic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microscopy, Fluorescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Models, Biological | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Patch-Clamp Techniques | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phospholipase C beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Isoforms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C-alpha | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Purkinje Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal Transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Time Factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type C Phospholipases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blotting, Western | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cerebellum | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enzyme Activation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isoenzymes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mice, Transgenic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microscopy, Fluorescence | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Models, Biological | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Patch-Clamp Techniques | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phospholipase C beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Isoforms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C beta | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Protein Kinase C-alpha | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Purkinje Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Signal Transduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Time Factors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Type C Phospholipases | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hirono, Moritoshi
× Hirono, Moritoshi× Sugiyama, Takashi× Kishimoto, Yasushi× Sakai, Ikuo× Miyazawa, Takahito× Kishio, Masahiro× Inoue, Hiroko× Nakao, Kazuki× Ikeda, Masayuki× Kawahara, Shigenori× Kirino, Yutaka× Katsuki, Motoya× Horie, Hidenori× Ishikawa, Yoshihiro× Yoshioka, Tohru |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Activation of the type-1 metabotropic glutamate receptor (mGluR1) signaling pathway in the cerebellum involves activation of phospholipase C (PLC) and protein kinase C (PKC) for the induction of cerebellar long term depression (LTD). The PLC and PKC isoforms that are involved in LTD remain unclear, however. One previous study found no change in LTD in PKCgamma-deficient mice, thus, in the present study, we examined cerebellar LTD in PLCbeta4-deficient mice. Immunohistochemical and Western blot analyses of cerebellum from wild-type mice revealed that PLCbeta1 was expressed weakly and uniformly, PLCbeta2 was not detected, PLCbeta3 was expressed predominantly in caudal cerebellum (lobes 7-10), and PLCbeta4 was expressed uniformly throughout. In PLCbeta4-deficient mice, expression of total PLCbeta, the mGluR1-mediated Ca(2+) response, and LTD induction were greatly reduced in rostral cerebellum (lobes 1-6). Furthermore, we used immunohistochemistry to localize PKCalpha, -betaI, -betaII, and -gamma in mouse cerebellar Purkinje cells during LTD induction. Both PKCalpha and PKCbetaI were found to be translocated to the plasmamembrane under these conditions. Taken together, these results suggest that mGluR1-mediated activation of PLCbeta4 in rostral cerebellar Purkinje cells induced LTD via PKCalpha and/or PKCbetaI. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of biological chemistry 276(48), 45236-45242.(2001) | |||||
書誌情報 |
The Journal of biological chemistry en : The Journal of biological chemistry 巻 276, 号 48, p. 45236-45242, 発行日 2001-11-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0021-9258 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 11551922 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1074/jbc.M105413200 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | Application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | American Society for Biochemistry and Molecular Biology | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |