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Effect of keishibukuryogan on genetic and dietary obesity models
http://hdl.handle.net/10110/00018129
http://hdl.handle.net/10110/00018129ef8bea7a-dd7f-4f7f-8a4e-5494cbc4e998
名前 / ファイル | ライセンス | アクション |
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EBCAM_2015_801291_Gao (2.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-08 | |||||
タイトル | ||||||
タイトル | Effect of keishibukuryogan on genetic and dietary obesity models | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Gao, Fengying
× Gao, Fengying× Yokoyama, Satoru× Fujimoto, Makoto× Tsuneyama, Koichi× Saiki, Ikuo× Shimada, Yutaka× Hayakawa, Yoshihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Obesity has been recognized as one of the most important risk factors for a variety of chronic diseases, such as diabetes, hypertension/cardiovascular diseases, steatosis/hepatitis, and cancer. Keishibukuryogan (KBG, Gui Zhi Fu Ling Wan in Chinese) is a traditional Chinese/Japanese (Kampo) medicine that has been known to improve blood circulation and is also known for its anti-inflammatory or scavenging effect. In this study, we evaluated the effect of KBG in two distinct rodent models of obesity driven by either a genetic (SHR/NDmcr-cp rat model) or dietary (high-fat diet-induced mouse obesity model) mechanism. Although there was no significant effect on the body composition in either the SHR rat or the DIO mouse models, KBG treatment significantly decreased the serum level of leptin and liver TG level in the DIO mouse, but not in the SHR rat model. Furthermore, a lower fat deposition in liver and a smaller size of adipocytes in white adipose tissue were observed in the DIO mice treated with KBG. Importantly, we further found downregulation of genes involved in lipid metabolism in the KBG-treated liver, along with decreased liver TG and cholesterol level. Our present data experimentally support in fact that KBG can be an attractive Kampo medicine to improve obese status through a regulation of systemic leptin level and/or lipid metabolism. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Evid Based Complement Alternat Med, 2015; 2015: 801291 | |||||
書誌情報 |
Evidence-Based Mental Health 巻 2015, 発行日 2015 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741427X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968793 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1155/2015/801291 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |