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Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)
http://hdl.handle.net/10110/2316
http://hdl.handle.net/10110/2316e8d81da4-3e10-4e7e-be40-004f89006576
名前 / ファイル | ライセンス | アクション |
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wakan05-suppl176.pdf (727.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-14 | |||||
タイトル | ||||||
タイトル | Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ashwagandha | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dementia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nootropic effect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synaptic regeneration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tohda, Chihiro
× Tohda, Chihiro× Komatsu, Katsuko× Kuboyama, Tomoharu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although Ashwagandha (root of Withania somnifera) has been used for multi purposes but mainly as a tonic in the traditional Indian Ayurvedic medicine, this review focused on nootropic effects of Ashwagandha itself and isolated compounds from it. Several reports showed sitoindosides VII-X as active compounds for cognitive enhancer. However, our study revealed other active constituents, withanolide A, withanoside IV and withanoside VI, could improve Aβ(25-35) induced memory impairment, neuronal atrophy and synaptic loss in the cerebral cortex and the hippocampus. Treatment with Aβ(25-35) induced axonal and dendritic atrophy, and pre-synaptic and post-synaptic losses also in cultured rat cortical neurons. Subsequent treatment with withanolide A, withanoside IV and withanoside VI induced significant reconstruction of pre-synapses and post-synapses, in addition to regeneration of both axons and dendrites in the neurons. Withanolide A, withanoside IV and withanoside VI are therefore important candidates for the therapeutic treatment of neurodegenerative diseases, as it is able to reconstruct neuronal networks. | |||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 22, 号 supll., p. 176-182, 発行日 2005 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18801447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
スポンサー | ||||||
内容記述タイプ | Other | |||||
内容記述 | Century COE program, Toyama Medical and Pharmaceutical University | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |