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Inhibitory effect of Kampo medicines on bone resorption in vitro and preventive effect on bone loss in vivo
http://hdl.handle.net/10110/1997
http://hdl.handle.net/10110/19977970783d-d1f9-4a1f-b323-ce4f6295ba86
名前 / ファイル | ライセンス | アクション |
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wakan06-92.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-28 | |||||
タイトル | ||||||
タイトル | Inhibitory effect of Kampo medicines on bone resorption in vitro and preventive effect on bone loss in vivo | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antiosteoporotic activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bu-Shen-Jian-Gu-Tang(補腎健骨湯) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peripheral quantitative computed tomography (pQCT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Chinese formula | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone resorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovariectomy (OVX) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SHI, Liying
× SHI, Liying× Tezuka, Yasuhiro× SUBE, HAN× Ueda, Jun-ya× Miyahara, Tatsuro× YIN, Jun× Nobukawa, Takahiro× Kadota, Shigetoshi |
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著者別名 | ||||||
姓名 | 門田, 重利 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The inhibitory activities of 19 Chinese formulae on osteoclast formation and bone resorption in vitro were investigated. The inhibitory activity on osteoclast formation was evaluated using a mouse bone marrow cell culture in which osteoclast-like multinucleated cells were formed in the presence of parathyroid hormone (PTH). The inhibitory activity on bone resoption was evaluated using PTH-induced resorption of ^<45>Ca from ^<45>Ca-prelabeled neonatal mouse parietal bone. Among the 19 Chinese formulae, nine showed a strong inhibitory activity on osteoclast formation at a concentration of 50 μg/ml, and three of the nine also showed a strong inhibitory activity on bone resorption. Among these three formulae, Bu-Shen-Jian-Gu-Tang (補腎健骨湯) showed the most promising activity in a dose-dependent manner on the inhibition of bone resorption. A further in vivo experiment in ovariectomized (OVX) model rats using peripheral quantitative computed tomography (pQCT) revealed its preventive effect on bone loss. 本研究では19種の漢方方剤によるin vitroでの破骨細胞形成及び骨吸収の抑制活性を検討した。破骨細胞形成抑制活性はマウス骨髄細胞培養系を用い,副甲状腺ホルモン(PTH)存在下での破骨細胞様多核細胞の形成により評価した。骨吸収抑制活性は^<45>Ca標識した新生児マウスの頭頂骨での,PTH誘導による^<45>Ca吸収を評価した。19種の漢方方剤のうち,9処方が50μg/mlの濃度で強い破骨細胞形成抑制活性を示し,この中で,3処方は骨吸収を強く抑制した。中でも,「補腎健骨湯」は用量依存的に骨吸収を抑制し,最も有望な活性を示した。さらに,卵巣摘出(OVX)ラットを用いたin vivoでの実験では, pQCT(末梢骨定量的コンピューター断層撮影法)での評価の結果,骨減少を予防する効果が認められた。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 23, 号 3, p. 92-100, 発行日 2006-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1880-1447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |