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Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats
http://hdl.handle.net/10110/1979
http://hdl.handle.net/10110/1979c585cca7-cc39-4641-809a-1be9954f162a
名前 / ファイル | ライセンス | アクション |
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19970301.pdf (900.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | paeoniflorin unilateral nucleus basalis magnocellularis lesion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | brightness discrimination task | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsumoto, Kinzo
× Matsumoto, Kinzo× Akazawa, Ko-hei× Murakami, Yukihisa× Shimizu, Mineo× Ichiki, Hiroyuki× Maruno, Masao× Watanabe, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of paeoniflorin on learning impairment of operant brightness discrimination performance was investigated in rats with unilateral nucleus basalis magnocellularis(NBM)lesion. The animals with unilateral NBM lesion exhibited a significant acquisition impairment of brightness discrimination task during the early phase of a training period(1-5days after starting the training session). When administered daily during a training period,paeoniflorin significantly improved the learning impairment of unilateral NBM-lesioned rats at 0.01 but not 0.1mg/kg/day(p.o.). Tacrine (0.3mg/kg/day,p.o.), a cholinesterase inhibitor,also significantly ameliorated the learning deficit. These results suggest that paeoniflorin improves the impairment of non-spatial learning performance caused by cholinergic dysfunction in rats and that it may have a beneficial effect on senile dementia. | |||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 14, 号 3, p. 163-168, 発行日 1997-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |