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Radical-scavenging activity of Wen-Pi-Tang and its component crude drugs : with special reference to the effects on nitric oxide, superoxide and peroxynitrite
http://hdl.handle.net/10110/1961
http://hdl.handle.net/10110/1961aeb6faf5-701e-4547-90ad-886b5718cfac
名前 / ファイル | ライセンス | アクション |
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20000106.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | Radical-scavenging activity of Wen-Pi-Tang and its component crude drugs : with special reference to the effects on nitric oxide, superoxide and peroxynitrite | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitric oxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | superoxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroxynitrite | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wen-Pi-Tang(温脾湯) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rhei Rhizoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Zingiberis Rhizoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Glycyrrhizae Radix | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wen-Pi-Tang | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 温脾湯 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hattori, Masao
× Hattori, Masao× CHUNG, HaeYoung× Yokozawa, Takako× Sekiya, Michiko× RHYU, DongYoung |
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著者別名 | ||||||
姓名 | 横澤, 隆子 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In renal diseases, active oxygen and free radicals play various roles in the development and progression of the pathological condition. Our previous studies have provided evidence that the Oriental medical prescription Wen-Pi-Tang normalizes the kidney under conditions of increased oxidative stress. In the present study, we examined the antioxidant capacity of Wen-Pi-Tang and its component crude drugs in a nitric oxide, superoxide and peroxynitrite generation system. It was found that the radical-scavenging effect of Wen-Pi-Tang is dose-dependent, and that three of its component crude drugs, i.e., Rhei Rhizoma, Zingiberis Rhizoma and Glycyrrhizae Radix, play important roles in the antioxidant action. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 腎疾患において活性酸素,フリーラジカルはさまざまな形でその病態の成立,進展に関与しているが,漢方方剤温脾湯が酸化的ストレス状態にある腎を是正する作用をこれまで報告してきた。本研究では温脾湯と構成和漢薬の抗酸化能をNO,O^-_2並ぴにONOO^-発生系を用い検討し,温脾湯によるこれらラジカル消去作用は用量依存的に認められ,また構成和漢薬では大黄,乾姜,甘草が重要な役割を担っていることが明らかとなった。 | |||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 17, 号 1, p. 41-47, 発行日 2000-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |