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After the administration of Toki-shakuyaku-san for four weeks, the flow volume rates of microcirculatory flow of the bulbar conjunctiva were increased (p\u003c0.05). Hemorheological factors such as whole blood viscosity, plasma viscosity, and erythrocyte deformability were examined. Toki-shakuyaku-san improved whole blood viscosity and erythrocyte deformability (p\u003c0.05), and plasma lipid peroxides decreased. 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Effects of Toki-shakuyaku-san on microcirculation of bulbar conjunctiva and hemorheological factors in patients with asymptomatic cerebral infarction
http://hdl.handle.net/10110/1385
http://hdl.handle.net/10110/1385976af42b-3993-4964-b310-92804fa1512c
名前 / ファイル | ライセンス | アクション |
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wakan04-yang.pdf (433.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-12-17 | |||||
タイトル | ||||||
タイトル | Effects of Toki-shakuyaku-san on microcirculation of bulbar conjunctiva and hemorheological factors in patients with asymptomatic cerebral infarction | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Toki-shakuyaku-san | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microcirculation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | asymptomatic cerebral infarction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | whole blood viscosity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | erythrocyte deformability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-oxidant effect | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
YANG, Qiao
× YANG, Qiao× Goto, Hirozo× Hikiami, Hiroaki× Shibahara, Naotoshi× Shimada, Yutaka× Terasawa, Katsutoshi× Tang, Fang |
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著者別名 | ||||||
姓名 | 後藤, 博三 | |||||
著者別名 | ||||||
姓名 | 嶋田, 豊 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this study, the effects of Toki-shakuyaku-san on the microcirculation of bulbar conjunctiva in 11 patients with asymptomatic cerebral infarction were investigated with a video-microscopic system. After the administration of Toki-shakuyaku-san for four weeks, the flow volume rates of microcirculatory flow of the bulbar conjunctiva were increased (p<0.05). Hemorheological factors such as whole blood viscosity, plasma viscosity, and erythrocyte deformability were examined. Toki-shakuyaku-san improved whole blood viscosity and erythrocyte deformability (p<0.05), and plasma lipid peroxides decreased. These results suggested that the favorable effects of Toki-shakuyaku-san on cerebrovascular disorders take place via changes in microcirculatory flow, with the mechanisms being considered to be improvements in hemorheological factors and the anti-oxidant effect of Toki-shakuyaku-san. 当帰芍薬散は陰虚証に用いられる代表的な駆〓血剤である。今回,無症候性脳梗塞患者に当帰芍薬散を投与し血液レオロジー因子等に及ぼす影響を検討した。対象は富山医科薬科大学附属病院和漢診療科外来通院中で頭部MRI上,無症候性脳梗塞と診断した患者11名(男性5名,女性6名,平均年齢59.5±8.2歳)である。方法は,当帰芍薬散投与前と4週後に,ビデオ顕微鏡システムを用い,眼球結膜微小血管を観察し,血管内径,血流速度,血流量を測定した。また,採血により血液粘度,赤血球変形能,過酸化脂質,一酸化窒素代謝物,フィブリノーゲン,赤血球数,Hb,Ht値等を測定した。結果は,当帰芍薬散の4週間の投与により,血圧には変化を認めなかったが,眼球結膜微小血管の血流量が増加し,血液レオロジー因子の全血粘度と赤血球変形能の改善を認めた。また,Hb,Ht値の上昇と過酸化脂質値の低下を認めた。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 21, 号 4, p. 170-174, 発行日 2004-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18801447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
スポンサー | ||||||
内容記述タイプ | Other | |||||
内容記述 | 21st Century COE Program, Toyama Medical and Pharmaceutical University | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |