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肝転移を抑制する漢方方剤における活性酸素消去能からみた特徴
https://doi.org/10.15099/00002534
https://doi.org/10.15099/000025342df76cc4-fa65-4d16-b3c2-58ad580c3451
名前 / ファイル | ライセンス | アクション |
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jns030015.pdf (756.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-12-21 | |||||
タイトル | ||||||
タイトル | 肝転移を抑制する漢方方剤における活性酸素消去能からみた特徴 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 漢方方剤 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 肝転移抑制 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 活性酸素 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ヒドロキシラジカル | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | harbal medicine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15099/00002534 | |||||
ID登録タイプ | JaLC | |||||
著者 |
小池, 潤
× 小池, 潤× 田澤, 賢次× 並川, 宏英× 伊藤, 佳代子× 八塚, 美樹× 安田, 智美× 小林, 祐子× 梶原, 睦子× 大上, 英夫× 斎藤, 智裕 |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Inhibitory effects on superoxide anion radical and hydroxyl radical by Chinese herbal with the preventive function for experimantal hepatic metastasis | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 十全大補湯, 四物湯, 補中益気湯, 小柴胡湯の経口投与は実験的ラット肝転移を抑制し, 十全大補湯と四物湯はマクロファージを, 補中益気湯はNK細胞を活性化するが, これら漢方方剤における活性酸素消去能の特徴を検討した.上記を含めて9種類の漢方方剤を検討したところ, ・O_2^-と・OH(Fenton反応・UV照射)の消去能の総和では小柴胡湯が最も強く, 温清飲, 補中益気湯十全大補湯四物湯人参養栄湯の順であった.更にこれら9種類の構成生薬23種類別における活性酸素消去能の検討の結果, 漢方方剤の特徴として十全大補湯, 四物湯温清飲は・O_2^-を, 補中益気湯と小柴胡湯は・OHを抑える傾向がみられ, ・O_2消去能の高い漢方方剤はマクロファージ活性に, ・OH消去能の高い漢方方剤はNK細胞活性に関与するという可能性が示唆された. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oral administration of Juzen-taiho-to , Shimotsu-to, Hochu-ekki-to, and Sho-saiko-to inhibits experimental liver metastasis. Juzen-taiho-to and Shimotsu-to activate macrophages, and also Hochu-ekki-to and Sho-saiko-to activate NK cells. The components that activate macrophages and NK cells in these Chinese herbal medicine (Juzen-taiho-to, Shimotsu-to, Shikunshi-to, Rikkunshi-to, Unsei-in, Ninjin-yoei-to, Toki-shakuyaksan, Hochu-ekki-to, and Sho-saiko-to) were examined for scavenging activity of free radicals. In 9 Chinese herbal medicine, the total intensity of scavenging activity on・O_2^-(HPX-XOD reaction) and・OH (Fenton Reaction, Ultra-Violet product) was Sho-saiko-to > Unsei-in > Hochu-ekki-to > Juzen-taiho-to > Shimotsu-to > Ninjin-yoei-to. In 23 crude components of 9 Chinese herbal medicines, ・O_2^- scavenging activity was highest in Jio, and ・ OH scavenging activity was highest in Kanzou. In conclusion, the potential for macrophage activation was indicated for components with a high ・ O_2^- scavenging ability, and NKcell activation was indicated for components with a high・OH scavenging ability. | |||||
書誌情報 |
富山医科薬科大学看護学会誌 巻 3, p. 153-160, 発行日 2000-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1344-1434 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11340152 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 富山医科薬科大学看護学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |