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Effects of Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) on endothelial function in spontaneously hypertensive rats
http://hdl.handle.net/10110/1943
http://hdl.handle.net/10110/194311decb38-d0ea-47a0-b258-2f36c59c7d1b
名前 / ファイル | ライセンス | アクション |
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20010303.pdf (873.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-24 | |||||
タイトル | ||||||
タイトル | Effects of Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) on endothelial function in spontaneously hypertensive rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spontaneously hypertensive rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelium-dependent relaxation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endothelium-dependent contraction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid peroxide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plasma viscosity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kasahara, Yuji
× Kasahara, Yuji× Goto, Hirozo× Shimada, Yutaka× Sekiya, Nobuyasu× Yang, Qiao× Terasawa, Katsutoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the protective effect of Keishi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) (KB) against vascular endothelial disorder in spontaneously hypertensive rats (SHR). We administered KB extract (400 mg/kg/day, p.o.) to SHR for 14 weeks. Blood pressure and plasma viscosity in the KB group were significantly lower than in the SHR control group without KB, and the endothelium-dependent relaxation rate by acetylcholine in the KB group was significantly higher than that in the SHR control group. The rate of endothelium-dependent contraction induced by oxygen-derived free radicals produced by the xanthine-xanthine oxidase system was significantly lower in the KB group than in the SHR control group, and plasma lipid peroxide concentration was also significantly lower in the KB group than in the SHR control group. These results suggest the possibility that KB prevents vascular complications due to hypertension. 自然発症高血圧ラット(SHR)における血管内皮障害に対する桂枝茯苓丸(KB)の保護作用について検討した。KBエキス(400mg/kg/day)は,経口で14週間SHRに投与した。KB群の血圧と血漿粘度は,SHR対照群と比較して有意に低下した。内皮依存性血管弛緩作用はSHR対照群と比較してKB群で有意に増加した。キサンチン-キサンチンオキシダーゼ系による内皮依存性血管収縮作用はSHR対照群と比較してKB群で有意に減少し,血漿過酸化脂質はKB群で有意に低下した。このことから,桂枝茯苓丸が,高血圧症による血管合併症を予防する可能性が示唆された。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 18, 号 3, p. 113-118, 発行日 2001-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |