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Discovery of novel adenylyl cyclase inhibitor by cell-based screening.
http://hdl.handle.net/10110/00018243
http://hdl.handle.net/10110/000182438e08046b-c122-4ad8-adc9-01b696cfa8f8
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_37_10_1689to1693_Toyooka (587.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-02 | |||||
タイトル | ||||||
タイトル | Discovery of novel adenylyl cyclase inhibitor by cell-based screening. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Discovery of novel adenylyl cyclase inhibitor by cell-based screening. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenylyl Cyclase Inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenylyl Cyclases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dose-Response Relationship, Drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug Discovery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug Evaluation, Preclinical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enzyme Inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HEK293 Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenylyl Cyclase Inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Adenylyl Cyclases | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Dose-Response Relationship, Drug | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug Discovery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug Evaluation, Preclinical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Enzyme Inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HEK293 Cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Humans | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mano, Hiroki
× Mano, Hiroki× Ishimoto, Tetsuya× Okada, Takuya× Toyooka, Naoki× Mori, Hisashi |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Discovery of novel adenylyl cyclase inhibitor by cell-based screening. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We screened 2400 compounds to find novel inhibitors of the adenylyl cyclase (AC)-protein kinase A (PKA)-cAMP response-element-binding protein (CREB) signaling pathway (AC/PKA/CREB pathway). Using a multistep cell-based screening system employing split luciferase technique, we narrowed down the candidates effectively from 2400 chemical compounds and identified a novel AC inhibitor (compound 1). Since dysregulation of the AC/PKA/CREB pathway is known to cause diseases not only in the nervous system but also in other organs, compound 1 is expected to be developed as a medicine for these diseases. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & pharmaceutical bulletin 37(10), 1689-1693.(2014) | |||||
書誌情報 |
Biological & pharmaceutical bulletin en : Biological & pharmaceutical bulletin 巻 37, 号 10, p. 1689-1693, 発行日 2014-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 25273392 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | THE PHARMACEUTICAL SOCIETY OF JAPAN | |||||
出版者 | ||||||
出版者 | 公益社団法人日本薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |