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Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats
http://hdl.handle.net/10110/00018232
http://hdl.handle.net/10110/000182326b375cee-82c4-489c-b094-5d7e055dc939
名前 / ファイル | ライセンス | アクション |
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JTraditionalMedicines_25_2_29to34_Toyooka (848.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-01 | |||||
タイトル | ||||||
タイトル | Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | swertiamarin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | swertiamarin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | metabolism | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gentianol | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wang, Zhigang
× Wang, Zhigang× Tang, Shuhan× Ma, Chaomei× Toyooka, Naoki× Kida, Hiroaki× Kawasaki, Masasi× Hattori, Masao |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Determination of novel nitrogen-containing metabolites after oral administration of swertiamarin to rats | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Wistar ラットを用いて伝統医療に用いられるスウェルチア植物の主成分である swertiamarin (1) の代謝研究をおこなった。 swertiamarin (1) を経口投与後, ラットの血漿を液体クロマトグラフィー/イオントラップマススペクトロメトリー法で分析し, 新規代謝物(R)-gentianol (4a)-gentianol (4b), 及び既知代謝物 gentianine (2) を同定した。 これら全ては窒素を含む代謝物であり, 代謝物の構造は, swertiamarin (1) から合成した標準化合物との HPLC での保持時間, MS, MS/MS スペクトルの直接比較により決定した。 (S)-gentianol (4b) を, gentianine (2) から得た gentianone (3) の立体選択的還元反応により合成し, その絶対立体配置を新モッシャー法により確定した。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the metabolic fate of swertiamarin (1) in Wistar rats. Swertiamarin (1) is a principal component of Swertia herbs used in traditional medicine. Liquid chromatography/ion trap mass spectrometry detected new metabolites (R)-gentianol (4a) and (S)-gentianol (4b) in rat plasma, together with the known metabolite gentianine (2), all of which contained nitrogen. The structures of the metabolites were identified by comparing the retention times, as well as MS and MS/MS spectra with those of authentic compounds, which were synthesized from swertiamarin (1). We prepared (S)-gentianol (4b) by stereoselective reduction from gentianone (3) which is a new oxidation product of gentianine (2), and the absolute configuration was unequivocally determined using an improved Mosher's method. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Traditional Medicines 25(2), 29-34.(2008) | |||||
書誌情報 |
Journal of Traditional Medicines en : Journal of Traditional Medicines 巻 25, 号 2, p. 29-34, 発行日 2008 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.11339/jtm.25.29 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130004495513 | |||||
出版者 | ||||||
出版者 | MEDICAL AND PHARMACEUTICAL SOCIETY FOR WAKAN-YAKU | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |