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Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small-cell lung cancer
http://hdl.handle.net/10110/00018126
http://hdl.handle.net/10110/00018126728ffe1b-fe42-4c5f-ae05-7a394f5ba7b0
名前 / ファイル | ライセンス | アクション |
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IntJOncol_46(4)_1844to1848_Toge (582.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-08 | |||||
タイトル | ||||||
タイトル | Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small-cell lung cancer | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | non-small cell lung cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | epithelial-to-mesenchymal transition | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemo-resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TGF-β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MCL-1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Toge, Masyoshi
× Toge, Masyoshi× Yokoyama, Satoru× Kato, Shinichiro× Sakurai, Hiroaki× Senda, Kazutaka× Doki, Yoshinori× Hayakawa, Yoshihiro× Yoshimura, Naoki× Saiki, Ikuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Non-small cell lung cancer (NSCLC) is one of the leading causes of death in all lung cancer patients due to its metastatic spread. Even though cisplatin treatment after surgical resection of the primary tumor has been established as a standard chemotherapy for residual disease including metastatic spread, NSCLC often acquires a resistance against chemotherapy, and metastatic disease is often observed. Amongst many potential mechanisms, epithelial-to-mesenchymal transition (EMT) has been considered as an important process in acquiring both metastatic spread and chemo-resistance of NSCLC. In this study, we identified MCL-1 as a critical molecule for chemoresistance in A549 cells associated with TGF-β-induced EMT. Importantly, downregulation of MCL-1 by siRNA or inhibition of MCL-1 with pan-BCL2 inhibitor to inhibit MCL-1 was able to overcome the EMT-associated chemo-resistance in A549 cells. Collectively, MCL-1 can be a new therapeutic target for overcoming EMT-associated chemo-resistance in NSCLC patients in the context of post-operative chemotherapies. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Oncology, 2015 Apr; 46(4): 1844-8 | |||||
書誌情報 |
International Journal of Oncology 巻 46, 号 4, p. 1844-1848, 発行日 2015-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10196439 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10992511 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3892/ijo.2015.2861 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article | |||||
関係URI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.3892/ijo.2015.2861 | |||||
関連名称 | 出版版へのリンク |