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Selective anti-cancer activity of Hirsutine against HER2 positive breast cancer cells by inducing DNA damage
http://hdl.handle.net/10110/00018124
http://hdl.handle.net/10110/00018124e6e0f75c-0e89-43c7-8b1b-fa2dd12e5a62
名前 / ファイル | ライセンス | アクション |
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OncolRep_33(4)_2072to2076_Lou (391.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-07 | |||||
タイトル | ||||||
タイトル | Selective anti-cancer activity of Hirsutine against HER2 positive breast cancer cells by inducing DNA damage | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HER2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apoptosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNA damage | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Lou, Chenghua
× Lou, Chenghua× Yokoyama, Satoru× Saiki, Ikuo× Hayakawa, Yoshihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hirsutine is one of the major alkaloids isolated from plants of the Uncaria genus and is known for its cardioprotective, anti‑hypertensive and anti-arrhythmic activities. We recently reported that hirsutine is an anti-metastatic phytochemical by targeting NF-κB activation in a murine breast cancer model. In the present study, we further examined the clinical utility of hirsutine against human breast cancer. Among six distinct human breast cancer cell lines, hirsutine showed strong cytotoxicity against HER2-positive/ p53-mutated MDA-MB‑453 and BT474 cell lines. Conversely, HER2-negative/p53 wild‑type MCF-7 and ZR-75-1 cell lines showed resistance against hirsutine-induced cytotoxicity. Hirsutine induced apoptotic cell death in the MDA-MB-453 cells, but not in the MCF-7 cells, through activation of caspases. Furthermore, hirsutine induced the DNA damage response in the MDA-MB-453 cells, but not in the MCF-7 cells, as highlighted by the upregulation of γH2AX expression. Along with the induction of the DNA damage response, the suppression of HER2, NF-κB and Akt pathways and the activation of the p38 MAPK pathway in the MDA-MB-453 cells were observed. Considering that there was no difference between MDA-MB-453 and MCF-7 cells in regards to irinotecan‑induced DNA damage response, our present results indicate the selective anticancer activity of hirsutine in HER2-positive breast cancer by inducing a DNA damage response. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncol Rep, 2015 Apr; 33(4): 2072-6 | |||||
書誌情報 |
Oncology Reports 巻 33, 号 4, p. 2072-2076, 発行日 2015-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1021-335X | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1791-2431 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3892/or.2015.3796 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | spandidos publications | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |